Malaghan Institute of Medical Research
Research en Wellington
www.malaghan.org.nz
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Dr Melanie McConnell received a PhD in biochemistry from the University of Otago, working to understand regulation of gene expression during kidney development. On her return to New Zealand, Melanie established the Cell Survival Research Group at the Malaghan Institute. The primary focus of my research is to understand how cancer cells survive stress, and to apply this knowledge to the development of more effective cancer therapies. We also use murine models of brain tumours, breast cancer and melanoma to study the different properties of cancer stem cells including self renewal, therapy resistance and metastasis. She then worked as an independent Scientific Member at the Basel Institute for Immunology, Switzerland, before being awarded a Malaghan Senior Research Fellowship to establish her research programme at the Malaghan Institute in 1994. Hermans I, Ritchie D, Roberts J, Yang J, Ronchese F CD8 T cell dependent elimination of dendritic cells in vivo limits the induction of anti tumor immunity. J Immunol, McCoy K, Hermans I, Fraser H, Le Gros G, Ronchese F Cytotoxic T lymphocyte associated antigen 4 CTLA 4 can regulate dendritic cell induced activation and cytotoxicity of CD8 T cells independently of CD4 T cell help. We are looking at the specific immune cell populations involved in eliciting effective immune responses to vaccination, including the dendritic cells responsible for stimulating T cells, and other less well known cells such as Natural Killer T NKT cells that contribute to the induced response. J Allergy Clin Immunol, Petersen TR, Dickgreber N, Hermans IF Tumor antigen presentation by dendritic cells. Therapies that activate the immune system immunotherapies have the potential to eli. Wellington’s Malaghan Institute of Medical Research has announced a 28 million boost. Leuk Res, Tan AS, Berridge MV Evidence for NAD P H quinone oxidoreductase 1 NQO1 mediated quinone dependent redox cycling via plasma membrane electron transport A sensitive ce
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Our cancer immunotherapies work by stimulating the body's immune system to fight cancer. Our vaccines programme is developing technologies that help the immune system target cancer cells more precisely. The Vaccine Therapy Programme investigating therapeutic vaccines that stimulate and promote particular immune cells to fight cancer. Gut inflammation researching the mechanisms that regulate intestinal homeostasis and gut health. Studying the molecules on the surface of a cell enables researchers to discover more about the processes going on inside a cell, as well as highlighting unexpected relationships between different types of cells. Dendritic cells are a specialised type of immune cell that are found in most tissues of the body where they control the activation of immune responses. Developing a vaccine for asthma dendritic cells are necessary for lung inflammation, so they are a potential target of immunotherapies to suppress disease. Professor Graham Le Gros leads resea
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